Consistently with the need for a modern, safe and innovative production line, CRF, in cooperation with Elasis, has been working for some time now on the development of new ICT methods and instruments for ergonomic analysis in the design phase in order to meet the increasingly pressing need to model workstations according to the operator’s anthropometric characteristics and to cater to the requirements of a vast product range. In this context, a method and related instrument for integrated anthropometric-altimetric ergonomic analysis of the line has been developed. The main purpose of the instrument is to define the altimetry and optimal percentile (from an ergonomic point of view) according to the sequence in which the operations are carried out (macro-cycle) and cycle time. Also, to meet the market’s growing demand for personalisation, parameterisation of the main dimensional characteristics of the products has been inserted in the instrument, permitting creation of a dynamic database that can be reconfigured according to the height of the line, the type of product and percentile of the operator. This type of instrument has been tested at different production sites: at Fiat Group Automobiles, it was adopted for analysis of the Lancia Ypsilon model (Cassino) and of the Fiat Panda model (Tichy), and at FPT Powertrain Technologies (Turin) for gearbox and engine design and is currently being extended to all production lines.